InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Msr1

Summary

InnateDB Protein

IDBP-627565.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Msr1

Protein Name

macrophage scavenger receptor 1

Synonyms

MRS-A; MSR; MSR-A; Scara1; Scvr; SR-AI; SR-AII;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132535

InnateDB Gene

IDBG-149582 (Msr1)

Protein Structure

UniProt Annotation

Function

Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0030169	low-density lipoprotein particle binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0010886	positive regulation of cholesterol storage
GO:0030301	cholesterol transport
GO:0034381	plasma lipoprotein particle clearance
GO:0042953	lipoprotein transport
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005581	collagen trimer
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle
GO:0034362	low-density lipoprotein particle