InnateDB Protein
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IDBP-627656.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sptssb
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Protein Name
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RIKEN cDNA 1110032A04 gene
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Synonyms
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1110032A04Rik; ADMP; Sssptb;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000131241
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InnateDB Gene
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IDBG-151769 (Sptssb)
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Protein Structure
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Function |
Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expression is strong in hypogonadal (hpg) mouse prostate, weak in mature castrated mouse prostate and absent in normal intact or androgen-replaced hpg mouse prostates. {ECO:0000269PubMed:15777716}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1913433
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InterPro |
IPR024512
Small subunit of serine palmitoyltransferase-like
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PFAM |
PF11779
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q925E8
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
66183
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UniGene |
Mm.45481
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RefSeq |
NP_001273888
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MGI ID |
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MGI Symbol |
Sptssb
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OMIM |
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CCDS |
CCDS38453
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HPRD |
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IMGT |
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EMBL |
AF365876
AK004017
AK009973
AK010117
BC022628
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GenPept |
AAH22628
AAK53702
BAC25062
BAC25279
BAC25280
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