InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Agtr1b

Summary

InnateDB Protein

IDBP-627829.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agtr1b

Protein Name

angiotensin II receptor, type 1b

Synonyms

Agtr-1b; Angtr-1b; AT1B; AT2R1B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128724

InnateDB Gene

IDBG-133637 (Agtr1b)

Protein Structure

UniProt Annotation

Function

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001596	angiotensin type I receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004945	angiotensin type II receptor activity
GO:0017046	peptide hormone binding
GO:0043621	protein self-association

Biological Process

GO:0001568	blood vessel development
GO:0001666	response to hypoxia
GO:0001822	kidney development
GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007584	response to nutrient
GO:0019229	regulation of vasoconstriction
GO:0042493	response to drug
GO:0042756	drinking behavior
GO:0043627	response to estrogen
GO:0071549	cellular response to dexamethasone stimulus
GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis

Cellular Component

GO:0012506	vesicle membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0031983	vesicle lumen

Protein Structure and Domains

PDB ID

MGI:87965

InterPro

IPR000190 Angiotensin II receptor type 1
IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR000496 Bradykinin receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00635
PR00241
PR00237
PR00657
PR00425

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P29755