Version 5.4
Mus musculus Protein: Inpp5d
Summary
InnateDB Protein IDBP-627895.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Inpp5d
Protein Name inositol polyphosphate-5-phosphatase D
Synonyms p150Ship; s-SHIP; SHIP; SHIP-1; SHIP1; SIP-145;
Species Mus musculus
Ensembl Protein ENSMUSP00000128700
InnateDB Gene IDBG-178553 (Inpp5d)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004445 inositol-polyphosphate 5-phosphatase activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0034594 phosphatidylinositol trisphosphate phosphatase activity
GO:0051425 PTB domain binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0008340 determination of adult lifespan
GO:0009968 negative regulation of signal transduction
GO:0016064 immunoglobulin mediated immune response
GO:0016311 dephosphorylation
GO:0030853 negative regulation of granulocyte differentiation
GO:0030889 negative regulation of B cell proliferation
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045409 negative regulation of interleukin-6 biosynthetic process
GO:0045579 positive regulation of B cell differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045656 negative regulation of monocyte differentiation
GO:0045659 negative regulation of neutrophil differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045779 negative regulation of bone resorption
GO:0050777 negative regulation of immune response
GO:0050869 negative regulation of B cell activation
Cellular Component
Protein Structure and Domains
PDB ID MGI:107357
InterPro IPR000980 SH2 domain
PFAM PF00017
PF14633
PRINTS PR00401
PIRSF
SMART SM00252
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9Q752
UniProt Splice Variant
Entrez Gene 16331
UniGene Mm.15105
RefSeq
MGI ID
MGI Symbol Inpp5d
OMIM
CCDS
HPRD
IMGT
EMBL AC102564 AC159967
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca