InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slit2

Summary

InnateDB Protein

IDBP-627907.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slit2

Protein Name

slit homolog 2 (Drosophila)

Synonyms

Drad-1; E030015M03Rik; E130320P19Rik; mKIAA4141; Slil3; slit-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133840

InnateDB Gene

IDBG-162862 (Slit2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0045499	chemorepellent activity

Biological Process

GO:0001656	metanephros development
GO:0001701	in utero embryonic development
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0008285	negative regulation of cell proliferation
GO:0010629	negative regulation of gene expression
GO:0016337	single organismal cell-cell adhesion
GO:0021772	olfactory bulb development
GO:0022029	telencephalon cell migration
GO:0030517	negative regulation of axon extension
GO:0031290	retinal ganglion cell axon guidance
GO:0033563	dorsal/ventral axon guidance
GO:0048812	neuron projection morphogenesis
GO:0050919	negative chemotaxis
GO:0060603	mammary gland duct morphogenesis
GO:0060763	mammary duct terminal end bud growth

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

MGI:1315205

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR000742 Epidermal growth factor-like domain
IPR001611 Leucine-rich repeat
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR003591 Leucine-rich repeat, typical subtype
IPR003645 Follistatin-like, N-terminal
IPR006207 Cystine knot, C-terminal
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM