InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slit2

Summary

InnateDB Gene

IDBG-162862.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slit2

Gene Name

slit homolog 2 (Drosophila)

Synonyms

Drad-1; E030015M03Rik; E130320P19Rik; mKIAA4141; Slil3; slit-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031558

Encoded Proteins

IDBP-162864

slit homolog 2 (Drosophila)

IDBP-627902

slit homolog 2 (Drosophila)

IDBP-627903

slit homolog 2 (Drosophila)

IDBP-627904

slit homolog 2 (Drosophila)

IDBP-627906

slit homolog 2 (Drosophila)

IDBP-627907

slit homolog 2 (Drosophila)

IDBP-627908

slit homolog 2 (Drosophila)

IDBP-627909

slit homolog 2 (Drosophila)

IDBP-627910

slit homolog 2 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145147:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:47983155-48306282

Strand

Forward strand

Band

Transcripts

ENSMUST00000033967	ENSMUSP00000033967
ENSMUST00000174061
ENSMUST00000172998
ENSMUST00000174313	ENSMUSP00000133912
ENSMUST00000170109	ENSMUSP00000127615
ENSMUST00000174421	ENSMUSP00000134263
ENSMUST00000173702	ENSMUSP00000134393
ENSMUST00000173107	ENSMUSP00000133840
ENSMUST00000173926
ENSMUST00000174658	ENSMUSP00000134359
ENSMUST00000173774
ENSMUST00000173303
ENSMUST00000174487
ENSMUST00000172824
ENSMUST00000172484
ENSMUST00000172493	ENSMUSP00000134655
ENSMUST00000173671
ENSMUST00000172561
ENSMUST00000173646
ENSMUST00000173686	ENSMUSP00000133382

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005095	GTPase inhibitor activity
GO:0005102	receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043237	laminin-1 binding
GO:0043394	proteoglycan binding
GO:0045499	chemorepellent activity
GO:0048495	Roundabout binding

Biological Process

GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0001701	in utero embryonic development
GO:0001933	negative regulation of protein phosphorylation
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0002689	negative regulation of leukocyte chemotaxis
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0008045	motor neuron axon guidance
GO:0008285	negative regulation of cell proliferation
GO:0010593	negative regulation of lamellipodium assembly
GO:0010596	negative regulation of endothelial cell migration
GO:0010629	negative regulation of gene expression
GO:0014912	negative regulation of smooth muscle cell migration
GO:0016337	single organismal cell-cell adhesion
GO:0021772	olfactory bulb development
GO:0021836	chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0021972	corticospinal neuron axon guidance through spinal cord
GO:0022029	telencephalon cell migration
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0030517	negative regulation of axon extension
GO:0030837	negative regulation of actin filament polymerization
GO:0031290	retinal ganglion cell axon guidance
GO:0032870	cellular response to hormone stimulus
GO:0033563	dorsal/ventral axon guidance
GO:0043065	positive regulation of apoptotic process
GO:0043086	negative regulation of catalytic activity
GO:0043116	negative regulation of vascular permeability
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048812	neuron projection morphogenesis
GO:0048846	axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0050929	induction of negative chemotaxis
GO:0051058	negative regulation of small GTPase mediated signal transduction
GO:0051414	response to cortisol
GO:0060603	mammary gland duct morphogenesis
GO:0060763	mammary duct terminal end bud growth
GO:0061364	apoptotic process involved in luteolysis
GO:0070100	negative regulation of chemokine-mediated signaling pathway
GO:0071504	cellular response to heparin
GO:0071672	negative regulation of smooth muscle cell chemotaxis
GO:0071676	negative regulation of mononuclear cell migration
GO:0090024	negative regulation of neutrophil chemotaxis
GO:0090260	negative regulation of retinal ganglion cell axon guidance
GO:0090288	negative regulation of cellular response to growth factor stimulus