Version 5.4
Mus musculus Protein: Crls1
Summary
InnateDB Protein IDBP-627983.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crls1
Protein Name cardiolipin synthase 1
Synonyms 0610009I22Rik; 4930557M15Rik; 5730490M08Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000132682
InnateDB Gene IDBG-207541 (Crls1)
Protein Structure
UniProt Annotation
Function Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
Subcellular Localization Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
Biological Process
GO:0008150 biological_process
GO:0008654 phospholipid biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1913836
InterPro IPR000462 CDP-alcohol phosphatidyltransferase
IPR004570 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
PFAM PF01066
PRINTS
PIRSF PIRSF000847
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80ZM8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 66586
UniGene
RefSeq NP_079922
MGI ID
MGI Symbol Crls1
OMIM
CCDS CCDS38247
HPRD
IMGT
EMBL AK016165 BC048702
GenPept AAH48702 BAB30134

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca