InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mecom

Summary

InnateDB Protein

IDBP-628096.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mecom

Protein Name

MDS1 and EVI1 complex locus

Synonyms

D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1; Mds1-Evi1; Prdm3; Znfpr1b1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133310

InnateDB Gene

IDBG-135456 (Mecom)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001780	neutrophil homeostasis
GO:0006954	inflammatory response
GO:0009617	response to bacterium
GO:0009791	post-embryonic development
GO:0030900	forebrain development
GO:0035115	embryonic forelimb morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0042127	regulation of cell proliferation
GO:0043069	negative regulation of programmed cell death
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046329	negative regulation of JNK cascade
GO:0051726	regulation of cell cycle
GO:0060039	pericardium development
GO:0072001	renal system development

Cellular Component

GO:0000118	histone deacetylase complex
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

MGI:95457

InterPro

IPR001214 SET domain
IPR003656 Zinc finger, BED-type predicted
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like

PFAM

PF00856
PF02892
PF00096

PRINTS

PIRSF

SMART

SM00317
SM00614
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

G3UZ13

UniProt Splice Variant

Entrez Gene

14013

UniGene

Mm.56965

RefSeq

XP_006535458

MGI ID

MGI Symbol

Mecom

OMIM

CCDS

HPRD

IMGT

EMBL

AC119995 AL683891 AL691419 AL772145 AL929377

GenPept