Version 5.4
Mus musculus Gene: Mecom
Summary
InnateDB Gene IDBG-135456.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mecom
Gene Name MDS1 and EVI1 complex locus
Synonyms D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1; Mds1-Evi1; Prdm3; Znfpr1b1
Species Mus musculus
Ensembl Gene ENSMUSG00000027684
Encoded Proteins
IDBP-135565
MDS1 and EVI1 complex locus
IDBP-264892
MDS1 and EVI1 complex locus
IDBP-264894
MDS1 and EVI1 complex locus
IDBP-628090
MDS1 and EVI1 complex locus
IDBP-628092
MDS1 and EVI1 complex locus
IDBP-628096
MDS1 and EVI1 complex locus
IDBP-628098
MDS1 and EVI1 complex locus
IDBP-628099
MDS1 and EVI1 complex locus
IDBP-628100
MDS1 and EVI1 complex locus
IDBP-628102
MDS1 and EVI1 complex locus
IDBP-628103
MDS1 and EVI1 complex locus
IDBP-628105
MDS1 and EVI1 complex locus
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085276:
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:29951299-30548008
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000061088 ENSMUSP00000051057
ENSMUST00000108271 ENSMUSP00000103906
ENSMUST00000108270 ENSMUSP00000103905
ENSMUST00000172694 ENSMUSP00000134303
ENSMUST00000173495 ENSMUSP00000134626
ENSMUST00000173059 ENSMUSP00000133310
ENSMUST00000174413 ENSMUSP00000134278
ENSMUST00000166001 ENSMUSP00000128563
ENSMUST00000173899 ENSMUSP00000133410
ENSMUST00000172697 ENSMUSP00000134117
ENSMUST00000172754 ENSMUSP00000134152
ENSMUST00000170212
ENSMUST00000174428
ENSMUST00000174406 ENSMUSP00000133942
ENSMUST00000173411
ENSMUST00000173022
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001780 neutrophil homeostasis
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0009617 response to bacterium
GO:0009791 post-embryonic development
GO:0030154 cell differentiation
GO:0030900 forebrain development
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0042127 regulation of cell proliferation
GO:0043069 negative regulation of programmed cell death
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046329 negative regulation of JNK cascade
GO:0051726 regulation of cell cycle
GO:0060039 pericardium development
GO:0071425 hematopoietic stem cell proliferation
GO:0072001 renal system development
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000085276
View Gene Order
ENSBTAG00000005871
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04010
MAPK signaling pathway pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3UY46
UniProt Splice Variant
Entrez Gene 14013
UniGene Mm.412121 Mm.488359 Mm.56965
RefSeq NM_007963 XM_006535387 XM_006535388 XM_006535389 XM_006535392 XM_006535393 XM_006535394
OMIM
CCDS CCDS17281
HPRD
IMGT
MGI ID MGI:95457
MGI Symbol Mecom
EMBL AC119995 AL683891 AL691419 AL772145 AL929377
GenPept
RNA Seq Atlas 14013

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca