InnateDB Protein
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IDBP-628136.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Aif1
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Protein Name
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allograft inflammatory factor 1
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Synonyms
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AI607846; AIF-1; D17H6S50E; G1; Iba1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000134214
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InnateDB Gene
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IDBG-177226 (Aif1)
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Protein Structure
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Function |
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. {ECO:0000269PubMed:10934045, ECO:0000269PubMed:11500035, ECO:0000269PubMed:11722645, ECO:0000269PubMed:11916959, ECO:0000269PubMed:14756805}.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.
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Disease Associations |
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Tissue Specificity |
Abundantly expressed in the testis, moderately in the spleen and lymph nodes and at low levels in the liver and thymus. Detected in macrophages. {ECO:0000269PubMed:11722645}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0001774
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microglial cell activation
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GO:0006911
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phagocytosis, engulfment
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GO:0006954
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inflammatory response
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GO:0016601
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Rac protein signal transduction
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GO:0030041
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actin filament polymerization
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GO:0042102
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positive regulation of T cell proliferation
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GO:0048661
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positive regulation of smooth muscle cell proliferation
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GO:0048662
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negative regulation of smooth muscle cell proliferation
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GO:0051017
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actin filament bundle assembly
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GO:0071346
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cellular response to interferon-gamma
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GO:0071672
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negative regulation of smooth muscle cell chemotaxis
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GO:0071673
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positive regulation of smooth muscle cell chemotaxis
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GO:0090026
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positive regulation of monocyte chemotaxis
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GO:0097178
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ruffle assembly
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GO:1900087
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positive regulation of G1/S transition of mitotic cell cycle
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GO:2000406
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positive regulation of T cell migration
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Cellular Component |
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PDB ID |
MGI:1343098
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InterPro |
IPR002048
EF-hand domain
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PFAM |
PF00036
PF13202
PF13405
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PRINTS |
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PIRSF |
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SMART |
SM00054
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TIGRFAMs |
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Modification |
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SwissProt |
O70200
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PhosphoSite |
PhosphoSite-O70200
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TrEMBL |
Q7TSW1
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UniProt Splice Variant |
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Entrez Gene |
11629
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UniGene |
Mm.10747
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RefSeq |
XP_006523565
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MGI ID |
1WY9
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MGI Symbol |
Aif1
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OMIM |
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CCDS |
CCDS28689
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HPRD |
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IMGT |
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EMBL |
AB013745
AB036423
AF074959
AF109719
AJ560665
AK006184
AK006562
BC021539
CH466666
CT010265
CT010385
D86382
EF101555
U82792
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GenPept |
AAC24189
AAC25604
AAC82481
AAH21539
ABK96804
BAA28216
BAA86387
BAB20758
BAB24445
BAB24654
CAD91187
CAJ18473
CAJ18592
EDL26636
EDL26637
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