InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: H2-D1

Summary

InnateDB Protein

IDBP-628175.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2-D1

Protein Name

histocompatibility 2, D region locus 1

Synonyms

H-2D; H-2L; H2-D;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000134570

InnateDB Gene

IDBG-177614 (H2-D1)

Protein Structure

UniProt Annotation

Function

Involved in the presentation of foreign antigens to the immune system.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0042605	peptide antigen binding

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002485	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
GO:0006955	immune response
GO:0019882	antigen processing and presentation

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0042612	MHC class I protein complex
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

MGI:95896

InterPro

IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR010579 MHC class I, alpha chain, C-terminal
IPR011162 MHC classes I/II-like antigen recognition protein
IPR027648 MHC class I alpha chain

PFAM

PF00129
PF07654
PF06623

PRINTS

PR01638

PIRSF

SMART

SM00407

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt