Version 5.4
Mus musculus Protein: Gabra6
Summary
InnateDB Protein IDBP-628204.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gabra6
Protein Name gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6
Synonyms alpha6; GABA-ARalpha6; Gabra-6;
Species Mus musculus
Ensembl Protein ENSMUSP00000126114
InnateDB Gene IDBG-163638 (Gabra6)
Protein Structure
UniProt Annotation
Function GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Only found in cerebellar granule cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:95618
InterPro IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
IPR005436 Gamma-aminobutyric-acid A receptor, alpha 6 subunit
IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
PFAM PF02932
PF02931
PRINTS PR01079
PR01619
PR00253
PR00252
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P16305
PhosphoSite PhosphoSite-P16305
TrEMBL
UniProt Splice Variant
Entrez Gene 14399
UniGene Mm.4915
RefSeq NP_001093111
MGI ID
MGI Symbol Gabra6
OMIM
CCDS CCDS48769
HPRD
IMGT
EMBL AF256197 AF256198 AK135145 AL645823 BC145158 BC145702 U77409 U77410 U77411 X51986
GenPept AAD52001 AAD52002 AAD52003 AAD52004 AAG28024 AAG28025 AAI45159 AAI45703 BAE22438 CAA36244 CAI24931

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca