Version 5.4
Mus musculus Protein: Cnga1
Summary
InnateDB Protein IDBP-628362.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cnga1
Protein Name cyclic nucleotide gated channel alpha 1
Synonyms Cncg;
Species Mus musculus
Ensembl Protein ENSMUSP00000132329
InnateDB Gene IDBG-169984 (Cnga1)
Protein Structure
UniProt Annotation
Function Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Rod cells in the retina and inner medulla of kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005222 intracellular cAMP activated cation channel activity
GO:0005223 intracellular cGMP activated cation channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0030553 cGMP binding
Biological Process
GO:0006811 ion transport
GO:0007601 visual perception
GO:0007603 phototransduction, visible light
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0042622 photoreceptor outer segment membrane
Protein Structure and Domains
PDB ID MGI:88436
InterPro IPR000595 Cyclic nucleotide-binding domain
IPR005821 Ion transport domain
IPR018490 Cyclic nucleotide-binding-like
PFAM PF00027
PF00520
PRINTS
PIRSF
SMART SM00100
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P29974
PhosphoSite PhosphoSite-P29974
TrEMBL
UniProt Splice Variant
Entrez Gene 12788
UniGene Mm.436652
RefSeq
MGI ID
MGI Symbol Cnga1
OMIM
CCDS CCDS19333
HPRD
IMGT
EMBL BC141261 M84742 U19715 U19716 U19717
GenPept AAA37425 AAA85700 AAA85701 AAA85702 AAI41262

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca