InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAP1

Summary

InnateDB Protein

IDBP-6299.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAP1

Protein Name

ArfGAP with dual PH domains 1

Synonyms

CENTA1; GCS1L; p42IP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000265846

InnateDB Gene

IDBG-6297 (ADAP1)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). {ECO:0000269PubMed:10448098, ECO:0000303PubMed:10333475, ECO:0000305}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.

Disease Associations

Tissue Specificity

Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes. {ECO:0000269PubMed:10448098}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding
GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0032312	regulation of ARF GTPase activity
GO:0043087	regulation of GTPase activity
GO:0043547	positive regulation of GTPase activity