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InnateDB Protein
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IDBP-63065.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NOSIP
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Protein Name
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nitric oxide synthase interacting protein
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000343497
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InnateDB Gene
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IDBG-63063 (NOSIP)
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Protein Structure
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| Function |
Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity. {ECO:0000269PubMed:11149895, ECO:0000269PubMed:15548660, ECO:0000269PubMed:16135813}.
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| Subcellular Localization |
Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle.
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| Disease Associations |
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| Tissue Specificity |
Expressed in heart, brain and lung. Present in endothelial cells (at protein level). {ECO:0000269PubMed:11149895}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
12
[view]
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| Protein-Protein |
10
[view]
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| Protein-DNA |
2
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
1 [view]
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR016818
Nitric oxide synthase-interacting
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| PFAM |
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| PRINTS |
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| PIRSF |
PIRSF023577
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q9Y314
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| TrEMBL |
M0QX85
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| UniProt Splice Variant |
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| Entrez Gene |
51070
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| UniGene |
Hs.7236
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| RefSeq |
XP_005259021
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| HUGO |
HGNC:17946
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| OMIM |
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| CCDS |
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| HPRD |
17642
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| IMGT |
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| EMBL |
AC010619
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| GenPept |
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Version 5.4