Version 5.4
Homo sapiens Gene: NOSIP
Summary
InnateDB Gene IDBG-63063.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOSIP
Gene Name nitric oxide synthase interacting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000142546
Encoded Proteins
IDBP-63065
nitric oxide synthase interacting protein
IDBP-761413
IDBP-760485
IDBP-760551
IDBP-761196
IDBP-763297
IDBP-763847
IDBP-760141
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49555711-49590262
Strand Reverse strand
Band q13.33
Transcripts
ENST00000339093 ENSP00000343497
ENST00000600019 ENSP00000471291
ENST00000593345
ENST00000601340
ENST00000598544 ENSP00000468974
ENST00000598839
ENST00000601015 ENSP00000470450
ENST00000601107
ENST00000599537 ENSP00000473109
ENST00000596358 ENSP00000470034
ENST00000598296 ENSP00000471929
ENST00000596477
ENST00000599425
ENST00000598820
ENST00000598550
ENST00000594932 ENSP00000472103
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0043086 negative regulation of catalytic activity
GO:0044281 small molecule metabolic process
GO:0046209 nitric oxide metabolic process
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051001 negative regulation of nitric-oxide synthase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003421
View Gene Order
ENSBTAG00000014450
Not yet available
Pathways
NETPATH
REACTOME
REACT_12510
NOSIP mediated eNOS trafficking pathway
REACT_12389
eNOS activation and regulation pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.7236
RefSeq NM_001270960 NM_015953 XM_005258964 XM_006723235
HUGO
OMIM
CCDS CCDS12772
HPRD 17642
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca