InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAMTOR1

Summary

InnateDB Protein

IDBP-63175.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMTOR1

Protein Name

late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000278671

InnateDB Gene

IDBG-63173 (LAMTOR1)

Protein Structure

UniProt Annotation

Function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. {ECO:0000269PubMed:19654316, ECO:0000269PubMed:20381137, ECO:0000269PubMed:20544018, ECO:0000269PubMed:22980980}.

Subcellular Localization

Late endosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Cell membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0032947	protein complex scaffold

Biological Process

GO:0001919	regulation of receptor recycling
GO:0007032	endosome organization
GO:0007040	lysosome organization
GO:0010872	regulation of cholesterol esterification
GO:0010874	regulation of cholesterol efflux
GO:0016049	cell growth
GO:0032008	positive regulation of TOR signaling
GO:0032418	lysosome localization
GO:0032439	endosome localization
GO:0034613	cellular protein localization
GO:0042632	cholesterol homeostasis
GO:0043410	positive regulation of MAPK cascade
GO:0043547	positive regulation of GTPase activity
GO:0060620	regulation of cholesterol import
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0031902	late endosome membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome
GO:0071986	Ragulator complex