Version 5.4
Homo sapiens Gene: LAMTOR1
Summary
InnateDB Gene IDBG-63173.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAMTOR1
Gene Name late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149357
Encoded Proteins
IDBP-63175
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
IDBP-583736
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
IDBP-598371
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
IDBP-600007
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
IDBP-602842
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
IDBP-595004
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:72085895-72103387
Strand Reverse strand
Band q13.4
Transcripts
ENST00000278671 ENSP00000278671
ENST00000545249 ENSP00000440738
ENST00000535107 ENSP00000445170
ENST00000544594 ENSP00000438717
ENST00000538404 ENSP00000439011
ENST00000535872 ENSP00000439482
ENST00000539797
ENST00000541403
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0032947 protein complex scaffold
Biological Process
GO:0001919 regulation of receptor recycling
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0010872 regulation of cholesterol esterification
GO:0010874 regulation of cholesterol efflux
GO:0016049 cell growth
GO:0032008 positive regulation of TOR signaling
GO:0032418 lysosome localization
GO:0032439 endosome localization
GO:0034613 cellular protein localization
GO:0042632 cholesterol homeostasis
GO:0043410 positive regulation of MAPK cascade
GO:0043547 positive regulation of GTPase activity
GO:0060620 regulation of cholesterol import
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0031902 late endosome membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
GO:0071986 Ragulator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030842
View Gene Order
ENSBTAG00000003001
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_017907
HUGO
OMIM
CCDS CCDS8209
HPRD 07933
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca