Version 5.4
Homo sapiens Protein: FOLR2
Summary
InnateDB Protein IDBP-63328.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOLR2
Protein Name folate receptor 2 (fetal)
Synonyms BETA-HFR; FBP; FBP/PL-1; FR-BETA; FR-P3;
Species Homo sapiens
Ensembl Protein ENSP00000298223
InnateDB Gene IDBG-63326 (FOLR2)
Protein Structure
UniProt Annotation
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. {ECO:0000269PubMed:23934049, ECO:0000269PubMed:2605182, ECO:0000269PubMed:4066659}.
Subcellular Localization Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. {ECO:0000269PubMed:2605182, ECO:0000269PubMed:8445646}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005542 folic acid binding
GO:0008517 folic acid transporter activity
Biological Process
GO:0015884 folic acid transport
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0031362 anchored component of external side of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR018143 Folate receptor-like
PFAM PF03024
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P14207
PhosphoSite PhosphoSite-P14207
TrEMBL F5H4Z6
UniProt Splice Variant
Entrez Gene 2350
UniGene Hs.433159
RefSeq NP_001107008
HUGO HGNC:3793
OMIM 136425
CCDS CCDS8212
HPRD 00637
IMGT
EMBL AK222643 AP000593 BC027894 BC058036 J02876 U02714 U02716 X69516
GenPept AAA17370 AAA35821 AAH27894 AAH58036 BAD96363 CAA49267

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca