InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUP153

Summary

InnateDB Protein

IDBP-63409.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUP153

Protein Name

nucleoporin 153kDa

Synonyms

HNUP153; N153;

Species

Homo sapiens

Ensembl Protein

ENSP00000262077

InnateDB Gene

IDBG-63405 (NUP153)

Protein Structure

UniProt Annotation

Function

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat- containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269PubMed:12802065, ECO:0000269PubMed:15229283, ECO:0000269PubMed:22253824}.

Subcellular Localization

Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Tightly associated with the nuclear membrane and lamina (By similarity). Localized to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Dissociates from the NPC structure early during prophase of mitosis. Integrated in the newly assembled nuclear envelope of postmitotic cells early in G1. Colocalized with NUP98 and TPR to the nuclear basket at the nucleoplasmic side of the NPC. Detected in diffuse and discrete intranuclear foci. Remained localized to the nuclear membrane after poliovirus (PV) infection. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	57 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005215	transporter activity
GO:0005487	nucleocytoplasmic transporter activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017056	structural constituent of nuclear pore
GO:0042802	identical protein binding
GO:0043495	protein anchor

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0015031	protein transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0046718	viral entry into host cell
GO:0046832	negative regulation of RNA export from nucleus
GO:0051028	mRNA transport
GO:0051292	nuclear pore complex assembly
GO:0055085	transmembrane transport
GO:0075732	viral penetration into host nucleus

Cellular Component

GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0031965	nuclear membrane
GO:0034399	nuclear periphery
GO:0042405	nuclear inclusion body
GO:0044615	nuclear pore nuclear basket