InnateDB Protein
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IDBP-63412.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SETD8
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Protein Name
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SET domain containing (lysine methyltransferase) 8
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000332995
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InnateDB Gene
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IDBG-63410 (SETD8)
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Protein Structure
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Function |
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. {ECO:0000269PubMed:12086618, ECO:0000269PubMed:12121615, ECO:0000269PubMed:15200950, ECO:0000269PubMed:15933069, ECO:0000269PubMed:15933070, ECO:0000269PubMed:16517599, ECO:0000269PubMed:17707234, ECO:0000269PubMed:23478445}.
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Subcellular Localization |
Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Colocalized with SIRT2 at mitotic foci. Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress- dependent manner. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
36
[view]
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Protein-Protein |
36
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0000278
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mitotic cell cycle
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GO:0006351
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transcription, DNA-templated
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GO:0007067
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mitotic nuclear division
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GO:0018026
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peptidyl-lysine monomethylation
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GO:0034968
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histone lysine methylation
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GO:0043516
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regulation of DNA damage response, signal transduction by p53 class mediator
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GO:0045892
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negative regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
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InterPro |
IPR001214
SET domain
IPR016858
Histone H4-K20 methyltransferase
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PFAM |
PF00856
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PRINTS |
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PIRSF |
PIRSF027717
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SMART |
SM00317
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NQR1
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PhosphoSite |
PhosphoSite-Q9NQR1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
387893
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UniGene |
Hs.674365
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RefSeq |
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HUGO |
HGNC:29489
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OMIM |
607240
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CCDS |
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HPRD |
06254
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IMGT |
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EMBL |
AF287261
AK292645
AY064546
AY102937
BC050346
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GenPept |
AAF97812
AAH50346
AAL40879
AAM47033
BAF85334
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