InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TBC1D25

Summary

InnateDB Protein

IDBP-63484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBC1D25

Protein Name

TBC1 domain family, member 25

Synonyms

MG81; OATL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000365962

InnateDB Gene

IDBG-63480 (TBC1D25)

Protein Structure

UniProt Annotation

Function

Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. {ECO:0000269PubMed:21383079}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21383079}. Cytoplasmic vesicle, autophagosome {ECO:0000269PubMed:21383079}. Note=It is dispersed in the cytoplasm under nutrient-rich conditions. Localizes at autophagosomes under cell starving conditions.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding
GO:0008483	transaminase activity

Biological Process

GO:0006914	autophagy
GO:0008152	metabolic process
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:1901096	regulation of autophagic vacuole maturation