InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMC4

Summary

InnateDB Protein

IDBP-63519.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMC4

Protein Name

structural maintenance of chromosomes 4

Synonyms

CAP-C; CAPC; hCAP-C; SMC-4; SMC4L1;

Species

Homo sapiens

Ensembl Protein

ENSP00000341382

InnateDB Gene

IDBG-63513 (SMC4)

Protein Structure

UniProt Annotation

Function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269PubMed:11136719}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10958694}. Cytoplasm {ECO:0000269PubMed:10958694}. Chromosome {ECO:0000269PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Disease Associations

Tissue Specificity

Widely expressed. Higher expression in testis, colon, thymus. {ECO:0000269PubMed:10319587}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.

Experimentally validated
Total	47 [view]
Protein-Protein	43 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000278	mitotic cell cycle
GO:0006935	chemotaxis
GO:0007076	mitotic chromosome condensation
GO:0007165	signal transduction
GO:0051276	chromosome organization

Cellular Component

GO:0000796	condensin complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003122 Chemotaxis methyl-accepting receptor, ligand-binding
IPR003395 RecF/RecN/SMC, N-terminal
IPR009053 Prefoldin
IPR010935 SMCs flexible hinge
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02203
PF02463
PF06470

PRINTS

PIRSF

SMART

SM00319
SM00968

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NTJ3