Version 5.4
Homo sapiens Protein: CHST10
Summary
InnateDB Protein IDBP-63567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHST10
Protein Name carbohydrate sulfotransferase 10
Synonyms HNK-1ST; HNK1ST;
Species Homo sapiens
Ensembl Protein ENSP00000264249
InnateDB Gene IDBG-63565 (CHST10)
Protein Structure
UniProt Annotation
Function Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis. {ECO:0000269PubMed:9478973}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart, pancreas, skeletal muscle, spleen and thymus, and weakly expressed in other tissues. In brain, it is expressed at higher level in the frontal lobe. {ECO:0000269PubMed:9478973}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0016232 HNK-1 sulfotransferase activity
Biological Process
GO:0007155 cell adhesion
GO:0007612 learning
GO:0007616 long-term memory
GO:0016051 carbohydrate biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR005331 Sulfotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF03567
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43529
PhosphoSite PhosphoSite-O43529
TrEMBL F5H3J3
UniProt Splice Variant
Entrez Gene 9486
UniGene Hs.595646
RefSeq NP_004845
HUGO HGNC:19650
OMIM 606376
CCDS CCDS2047
HPRD 07332
IMGT
EMBL AC012493 AF033827 AF070594 AK313241 BC010441 CH471127
GenPept AAC04707 AAC28651 AAH10441 AAX93044 BAG36052 EAX01841 EAX01842 EAX01843 EAX01844

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca