InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDCL3

Summary

InnateDB Protein

IDBP-63627.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDCL3

Protein Name

phosducin-like 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000264254

InnateDB Gene

IDBG-63625 (PDCL3)

Protein Structure

UniProt Annotation

Function

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination. {ECO:0000269PubMed:15371430, ECO:0000269PubMed:23792958}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15371430}.

Disease Associations

Tissue Specificity

Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon. {ECO:0000269PubMed:15371430}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043184	vascular endothelial growth factor receptor 2 binding
GO:0044183	protein binding involved in protein folding

Biological Process

GO:0001525	angiogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006457	protein folding
GO:0006915	apoptotic process
GO:0016032	viral process
GO:0045766	positive regulation of angiogenesis
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process