InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCL2L1

Summary

InnateDB Protein

IDBP-63675.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL2L1

Protein Name

BCL2-like 1

Synonyms

Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52;

Species

Homo sapiens

Ensembl Protein

ENSP00000302564

InnateDB Gene

IDBG-63673 (BCL2L1)

Protein Structure

UniProt Annotation

Function

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles.Isoform Bcl-X(S) promotes apoptosis.

Subcellular Localization

Isoform Bcl-X(L): Mitochondrion inner membrane {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49. {ECO:0000250}.

Disease Associations

Tissue Specificity

Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 177 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	177 [view]
Protein-Protein	173 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051434	BH3 domain binding

Biological Process

GO:0000910	cytokinesis
GO:0001541	ovarian follicle development
GO:0001701	in utero embryonic development
GO:0001836	release of cytochrome c from mitochondria
GO:0006897	endocytosis
GO:0006915	apoptotic process
GO:0007093	mitotic cell cycle checkpoint
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008584	male gonad development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637	apoptotic mitochondrial changes
GO:0009314	response to radiation
GO:0009566	fertilization
GO:0009615	response to virus
GO:0010507	negative regulation of autophagy
GO:0019050	suppression by virus of host apoptotic process
GO:0034097	response to cytokine
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0040007	growth
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response
GO:0046898	response to cycloheximide
GO:0046902	regulation of mitochondrial membrane permeability
GO:0051402	neuron apoptotic process
GO:0051881	regulation of mitochondrial membrane potential
GO:0060154	cellular process regulating host cell cycle in response to virus
GO:0070584	mitochondrion morphogenesis
GO:0071230	cellular response to amino acid stimulus
GO:0071312	cellular response to alkaloid
GO:0071480	cellular response to gamma radiation
GO:0071839	apoptotic process in bone marrow
GO:0090005	negative regulation of establishment of protein localization to plasma membrane
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097284	hepatocyte apoptotic process
GO:1900118	negative regulation of execution phase of apoptosis
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000811	negative regulation of anoikis
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0031965	nuclear membrane
GO:0031966	mitochondrial membrane
GO:0097136	Bcl-2 family protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR002475 Bcl2-like
IPR003093 Apoptosis regulator, Bcl-2 protein, BH4
IPR004725 Apoptosis regulator, Bcl-2/ BclX
IPR013279 Apoptosis regulator, Bcl-X
IPR026298 Blc2 family

PFAM

PF02180
PF00452

PRINTS

PR01864
PR01862

PIRSF

SMART

SM00265

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt