InnateDB Protein
|
IDBP-63681.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
BCL2L1
|
Protein Name
|
BCL2-like 1
|
Synonyms
|
Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000365223
|
InnateDB Gene
|
IDBG-63673 (BCL2L1)
|
Protein Structure
|
|
Function |
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles.Isoform Bcl-X(S) promotes apoptosis.
|
Subcellular Localization |
Isoform Bcl-X(L): Mitochondrion inner membrane {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 177 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
177
[view]
|
Protein-Protein |
173
[view]
|
Protein-DNA |
2
[view]
|
Protein-RNA |
0
|
DNA-DNA |
2
[view]
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
8 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0000910
|
cytokinesis
|
GO:0001836
|
release of cytochrome c from mitochondria
|
GO:0006897
|
endocytosis
|
GO:0006915
|
apoptotic process
|
GO:0007093
|
mitotic cell cycle checkpoint
|
GO:0008637
|
apoptotic mitochondrial changes
|
GO:0010507
|
negative regulation of autophagy
|
GO:0019050
|
suppression by virus of host apoptotic process
|
GO:0034097
|
response to cytokine
|
GO:0035872
|
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
|
GO:0042981
|
regulation of apoptotic process
|
GO:0043066
|
negative regulation of apoptotic process
|
GO:0045087
|
innate immune response
|
GO:0046902
|
regulation of mitochondrial membrane permeability
|
GO:0051881
|
regulation of mitochondrial membrane potential
|
GO:0090005
|
negative regulation of establishment of protein localization to plasma membrane
|
GO:0090201
|
negative regulation of release of cytochrome c from mitochondria
|
GO:0097192
|
extrinsic apoptotic signaling pathway in absence of ligand
|
GO:0097193
|
intrinsic apoptotic signaling pathway
|
GO:1900118
|
negative regulation of execution phase of apoptosis
|
GO:1902230
|
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
|
GO:2000811
|
negative regulation of anoikis
|
GO:2001240
|
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001243
|
negative regulation of intrinsic apoptotic signaling pathway
|
GO:2001244
|
positive regulation of intrinsic apoptotic signaling pathway
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR002475
Bcl2-like
IPR003093
Apoptosis regulator, Bcl-2 protein, BH4
IPR013279
Apoptosis regulator, Bcl-X
|
PFAM |
PF02180
|
PRINTS |
PR01864
|
PIRSF |
|
SMART |
SM00265
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q07817
|
PhosphoSite |
PhosphoSite-Q07817
|
TrEMBL |
Q5TE63
|
UniProt Splice Variant |
|
Entrez Gene |
598
|
UniGene |
Hs.516966
|
RefSeq |
NP_001182
|
HUGO |
HGNC:992
|
OMIM |
600039
|
CCDS |
CCDS13188
|
HPRD |
02497
|
IMGT |
|
EMBL |
AK290968
AL117381
AL160175
BC019307
BT007208
CH471077
CR936637
U72398
Z23115
Z23116
|
GenPept |
AAB17354
AAH19307
AAP35872
BAF83657
CAA80661
CAA80662
CAI12811
CAI23025
CAI56777
EAW76424
EAW76425
EAW76427
EAW76428
EAW76429
|
|
|