InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SUV39H1

Summary

InnateDB Protein

IDBP-63771.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUV39H1

Protein Name

suppressor of variegation 3-9 homolog 1 (Drosophila)

Synonyms

H3-K9-HMTase 1; KMT1A; MG44; SUV39H;

Species

Homo sapiens

Ensembl Protein

ENSP00000365877

InnateDB Gene

IDBG-63769 (SUV39H1)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. {ECO:0000269PubMed:14765126, ECO:0000269PubMed:16449642, ECO:0000269PubMed:16818776, ECO:0000269PubMed:16858404, ECO:0000269PubMed:18004385, ECO:0000269PubMed:18485871}.

Subcellular Localization

Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 256 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	256 [view]
Protein-Protein	252 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0018024	histone-lysine N-methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0046974	histone methyltransferase activity (H3-K9 specific)
GO:0047485	protein N-terminus binding

Biological Process

GO:0000183	chromatin silencing at rDNA
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006364	rRNA processing
GO:0007049	cell cycle
GO:0016032	viral process
GO:0030154	cell differentiation
GO:0034968	histone lysine methylation
GO:0036123	histone H3-K9 dimethylation
GO:0036124	histone H3-K9 trimethylation
GO:0042754	negative regulation of circadian rhythm
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048511	rhythmic process

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000792	heterochromatin
GO:0000794	condensed nuclear chromosome
GO:0005634	nucleus
GO:0005652	nuclear lamina
GO:0005654	nucleoplasm
GO:0005677	chromatin silencing complex
GO:0033553	rDNA heterochromatin

Protein Structure and Domains

PDB ID

InterPro

IPR000953 Chromo domain/shadow
IPR001214 SET domain
IPR003606 Pre-SET zinc-binding sub-group
IPR003616 Post-SET domain
IPR007728 Pre-SET domain
IPR011381 Histone H3-K9 methyltransferase
IPR016197 Chromo domain-like
IPR023780 Chromo domain

PFAM

PF00856
PF05033
PF00385

PRINTS

PIRSF

PIRSF009343

SMART

SM00298
SM00317
SM00468
SM00508

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt