Version 5.4
Homo sapiens Gene: SUV39H1
Summary
InnateDB Gene IDBG-63769.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUV39H1
Gene Name suppressor of variegation 3-9 homolog 1 (Drosophila)
Synonyms H3-K9-HMTase 1; KMT1A; MG44; SUV39H
Species Homo sapiens
Ensembl Gene ENSG00000101945
Encoded Proteins
IDBP-63771
suppressor of variegation 3-9 homolog 1 (Drosophila)
IDBP-63773
suppressor of variegation 3-9 homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression. [provided by RefSeq, Jul 2008]
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:48695554-48709012
Strand Forward strand
Band p11.23
Transcripts
ENST00000376687 ENSP00000365877
ENST00000337852 ENSP00000337976
ENST00000482260
ENST00000462786
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 256 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 256 [view]
Protein-Protein 252 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0018024 histone-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0046974 histone methyltransferase activity (H3-K9 specific)
GO:0047485 protein N-terminus binding
Biological Process
GO:0000183 chromatin silencing at rDNA
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006364 rRNA processing
GO:0007049 cell cycle
GO:0016032 viral process
GO:0030154 cell differentiation
GO:0034968 histone lysine methylation
GO:0036123 histone H3-K9 dimethylation
GO:0036124 histone H3-K9 trimethylation
GO:0042754 negative regulation of circadian rhythm
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048511 rhythmic process
GO:0051567 histone H3-K9 methylation
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000792 heterochromatin
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005652 nuclear lamina
GO:0005654 nucleoplasm
GO:0005677 chromatin silencing complex
GO:0033553 rDNA heterochromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039231
View Gene Order
ENSBTAG00000004706
Not yet available
Pathways
NETPATH
REACTOME
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_200827
SIRT1 negatively regulates rRNA Expression pathway
REACT_71
Gene Expression pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.522639
RefSeq NM_001282166 NM_003173
HUGO
OMIM
CCDS CCDS14304 CCDS65252
HPRD 02221
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca