InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SUV39H1

Summary

InnateDB Protein

IDBP-63773.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUV39H1

Protein Name

suppressor of variegation 3-9 homolog 1 (Drosophila)

Synonyms

H3-K9-HMTase 1; KMT1A; MG44; SUV39H;

Species

Homo sapiens

Ensembl Protein

ENSP00000337976

InnateDB Gene

IDBG-63769 (SUV39H1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 256 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	256 [view]
Protein-Protein	252 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0018024	histone-lysine N-methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0046974	histone methyltransferase activity (H3-K9 specific)
GO:0047485	protein N-terminus binding

Biological Process

GO:0000183	chromatin silencing at rDNA
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006364	rRNA processing
GO:0007049	cell cycle
GO:0016032	viral process
GO:0030154	cell differentiation
GO:0034968	histone lysine methylation
GO:0036123	histone H3-K9 dimethylation
GO:0036124	histone H3-K9 trimethylation
GO:0042754	negative regulation of circadian rhythm
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048511	rhythmic process
GO:0051567	histone H3-K9 methylation

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000792	heterochromatin
GO:0000794	condensed nuclear chromosome
GO:0005634	nucleus
GO:0005652	nuclear lamina
GO:0005654	nucleoplasm
GO:0005677	chromatin silencing complex
GO:0033553	rDNA heterochromatin

Protein Structure and Domains

PDB ID

InterPro

IPR000953 Chromo domain/shadow
IPR001214 SET domain
IPR003606 Pre-SET zinc-binding sub-group
IPR003616 Post-SET domain
IPR007728 Pre-SET domain
IPR011381 Histone H3-K9 methyltransferase
IPR016197 Chromo domain-like
IPR023780 Chromo domain

PFAM

PF00856
PF05033
PF00385

PRINTS

PIRSF

PIRSF009343

SMART

SM00298
SM00317
SM00468
SM00508

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt