InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TPX2

Summary

InnateDB Protein

IDBP-63820.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPX2

Protein Name

TPX2, microtubule-associated, homolog (Xenopus laevis)

Synonyms

C20orf1; C20orf2; DIL-2; DIL2; FLS353; GD:C20orf1; HCA519; HCTP4; p100; REPP86;

Species

Homo sapiens

Ensembl Protein

ENSP00000300403

InnateDB Gene

IDBG-63816 (TPX2)

Protein Structure

UniProt Annotation

Function

Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. {ECO:0000269PubMed:18663142, ECO:0000269PubMed:19208764}.

Subcellular Localization

Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.

Disease Associations

Tissue Specificity

Expressed in lung carcinoma cell lines but not in normal lung tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.

Experimentally validated
Total	43 [view]
Protein-Protein	41 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0019901	protein kinase binding

Biological Process

GO:0006915	apoptotic process
GO:0007067	mitotic nuclear division
GO:0008283	cell proliferation
GO:0032147	activation of protein kinase activity
GO:0060236	regulation of mitotic spindle organization

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005874	microtubule
GO:0015630	microtubule cytoskeleton
GO:0043203	axon hillock