InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCHE

Summary

InnateDB Protein

IDBP-63836.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCHE

Protein Name

butyrylcholinesterase

Synonyms

CHE1; CHE2; E1;

Species

Homo sapiens

Ensembl Protein

ENSP00000264381

InnateDB Gene

IDBG-63834 (BCHE)

Protein Structure

UniProt Annotation

Function

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. {ECO:0000269PubMed:19452557, ECO:0000269PubMed:19542320}.

Subcellular Localization

Secreted {ECO:0000269PubMed:19368529, ECO:0000269PubMed:19542320}.

Disease Associations

Butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]: A metabolic disorder characterized by prolonged apnea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnea varies significantly depending on the extent of the enzyme deficiency. {ECO:0000269PubMed:10404729, ECO:0000269PubMed:11928765, ECO:0000269PubMed:12881446, ECO:0000269PubMed:1306123, ECO:0000269PubMed:1349196, ECO:0000269PubMed:1415224, ECO:0000269PubMed:15563885, ECO:0000269PubMed:1611188, ECO:0000269PubMed:16788378, ECO:0000269PubMed:18075469, ECO:0000269PubMed:2915989, ECO:0000269PubMed:7634491, ECO:0000269PubMed:8554068, ECO:0000269PubMed:8680411, ECO:0000269PubMed:9110359, ECO:0000269PubMed:9191541, ECO:0000269PubMed:9388484, ECO:0000269PubMed:9543549, ECO:0000269PubMed:9694584}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Detected in blood plasma (at protein level). Present in most cells except erythrocytes. {ECO:0000269PubMed:19368529, ECO:0000269PubMed:19542320}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0003824	catalytic activity
GO:0003990	acetylcholinesterase activity
GO:0004104	cholinesterase activity
GO:0016787	hydrolase activity
GO:0019899	enzyme binding
GO:0033265	choline binding
GO:0042802	identical protein binding

Biological Process

GO:0007271	synaptic transmission, cholinergic
GO:0007584	response to nutrient
GO:0007612	learning
GO:0008152	metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0014016	neuroblast differentiation
GO:0019695	choline metabolic process
GO:0042493	response to drug
GO:0043279	response to alkaloid
GO:0044267	cellular protein metabolic process
GO:0050783	cocaine metabolic process
GO:0050805	negative regulation of synaptic transmission
GO:0051384	response to glucocorticoid
GO:0051593	response to folic acid

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005641	nuclear envelope lumen
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0016020	membrane
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR000997 Cholinesterase
IPR002018 Carboxylesterase, type B
IPR013094 Alpha/beta hydrolase fold-3
IPR014788 Acetylcholinesterase, tetramerisation domain
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00135
PF07859
PF08674

PRINTS

PR00878

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P06276