InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BCHE

Summary

InnateDB Gene

IDBG-63834.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCHE

Gene Name

butyrylcholinesterase

Synonyms

CHE1; CHE2; E1

Species

Homo sapiens

Ensembl Gene

ENSG00000114200

Encoded Proteins

IDBP-63836

butyrylcholinesterase

IDBP-479846

butyrylcholinesterase

IDBP-473340

butyrylcholinesterase

IDBP-480975

butyrylcholinesterase

IDBP-483276

butyrylcholinesterase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:165772904-165837472

Strand

Reverse strand

Band

q26.1

Transcripts

ENST00000264381	ENSP00000264381
ENST00000497011	ENSP00000419505
ENST00000482958	ENSP00000419804
ENST00000479451	ENSP00000418325
ENST00000488954	ENSP00000418504

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0003824	catalytic activity
GO:0003990	acetylcholinesterase activity
GO:0004104	cholinesterase activity
GO:0016787	hydrolase activity
GO:0019899	enzyme binding
GO:0033265	choline binding
GO:0042802	identical protein binding

Biological Process

GO:0007271	synaptic transmission, cholinergic
GO:0007584	response to nutrient
GO:0007612	learning
GO:0008152	metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0014016	neuroblast differentiation
GO:0019695	choline metabolic process
GO:0042493	response to drug
GO:0043279	response to alkaloid
GO:0044267	cellular protein metabolic process
GO:0050783	cocaine metabolic process
GO:0050805	negative regulation of synaptic transmission
GO:0051384	response to glucocorticoid
GO:0051593	response to folic acid

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005641	nuclear envelope lumen
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0016020	membrane
GO:0072562	blood microparticle