InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCOR2

Summary

InnateDB Protein

IDBP-63913.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCOR2

Protein Name

nuclear receptor corepressor 2

Synonyms

CTG26; N-CoR2; SMAP270; SMRT; SMRTE; SMRTE-tau; TNRC14; TRAC; TRAC-1; TRAC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000348551

InnateDB Gene

IDBG-63911 (NCOR2)

Protein Structure

UniProt Annotation

Function

Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. {ECO:0000269PubMed:18212045, ECO:0000269PubMed:23911289}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous. High levels of expression are detected in lung, spleen and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 188 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	188 [view]
Protein-Protein	173 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005112	Notch binding
GO:0005515	protein binding
GO:0042826	histone deacetylase binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0010467	gene expression
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0072365	regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter