Version 5.4
Homo sapiens Protein: IL1R2
Summary
InnateDB Protein IDBP-64055.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL1R2
Protein Name interleukin 1 receptor, type II
Synonyms CD121b; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2; IL1R2c; IL1RB;
Species Homo sapiens
Ensembl Protein ENSP00000330959
InnateDB Gene IDBG-64053 (IL1R2)
Protein Structure
UniProt Annotation
Function Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269PubMed:10975853, ECO:0000269PubMed:12530978, ECO:0000269PubMed:7989776, ECO:0000269PubMed:9862719}.
Subcellular Localization Isoform Short: Secreted {ECO:0000269PubMed:8702856}.Isoform Long: Cell membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004908 interleukin-1 receptor activity
GO:0004910 interleukin-1, Type II, blocking receptor activity
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0019221 cytokine-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR004074 Interleukin-1 receptor type I/II
IPR004077 Interleukin-1 receptor type II
IPR007110 Immunoglobulin-like domain
IPR013151 Immunoglobulin
PFAM PF00047
PRINTS PR01536
PR01539
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P27930
PhosphoSite PhosphoSite-P27930
TrEMBL C9JNR0
UniProt Splice Variant
Entrez Gene 7850
UniGene Hs.25333
RefSeq NP_004624
HUGO HGNC:5994
OMIM 147811
CCDS CCDS2054
HPRD 00995
IMGT
EMBL AC005035 AC007165 AY124010 BC039031 CH471127 U64094 U74649 X59770
GenPept AAB05878 AAD00242 AAH39031 AAK52072 AAM64221 CAA42441 EAX01800 EAX01801 EAX01802 EAX01803

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca