Homo sapiens Gene: IL1R2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-64053.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | IL1R2 | ||||||||||||||||||
Gene Name | interleukin 1 receptor, type II | ||||||||||||||||||
Synonyms | CD121b; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2; IL1R2c; IL1RB | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000115590 | ||||||||||||||||||
Encoded Proteins |
interleukin 1 receptor, type II
interleukin 1 receptor, type II
interleukin 1 receptor, type II
interleukin 1 receptor, type II
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||
Summary |
IL1R2 binds to IL1A to limit post-necrotic inflammation.
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InnateDB Annotation from Orthologs | |||||||||||||||||||
Summary |
[Mus musculus] Adam17 affects sensitivity to interleukin-1 by changing the balance between Il1r1 and Il1r2 receptors.
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Entrez Gene | |||||||||||||||||||
Summary |
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 2:101991844-102028544 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q11.2 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH |
IL1 pathway
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REACTOME |
Interleukin-1 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
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KEGG |
Hematopoietic cell lineage pathway
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Amoebiasis pathway
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INOH |
JAK STAT pathway and regulation pathway
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PID NCI |
IL1-mediated signaling events
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.25333 | ||||||||||||||||||
RefSeq | NM_001261419 NM_004633 XM_006712734 XM_006712736 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS2054 CCDS58719 | ||||||||||||||||||
HPRD | 00995 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||