InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UCP3

Summary

InnateDB Protein

IDBP-64085.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UCP3

Protein Name

uncoupling protein 3 (mitochondrial, proton carrier)

Synonyms

SLC25A9;

Species

Homo sapiens

Ensembl Protein

ENSP00000323740

InnateDB Gene

IDBG-64083 (UCP3)

Protein Structure

UniProt Annotation

Function

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269PubMed:9769326, ECO:0000269Ref.9}. Note=The gene represented in this entry may be involved in disease pathogenesis.

Tissue Specificity

Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles. {ECO:0000269PubMed:9196039}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0017077	oxidative phosphorylation uncoupler activity

Biological Process

GO:0000303	response to superoxide
GO:0001666	response to hypoxia
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006839	mitochondrial transport
GO:0007568	aging
GO:0007584	response to nutrient
GO:0007585	respiratory gaseous exchange
GO:0009409	response to cold
GO:0014823	response to activity
GO:0015992	proton transport
GO:0022904	respiratory electron transport chain
GO:0032868	response to insulin
GO:0032870	cellular response to hormone stimulus
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0048545	response to steroid hormone
GO:0051384	response to glucocorticoid

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002030 Mitochondrial brown fat uncoupling protein
IPR002067 Mitochondrial carrier protein
IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain

PFAM

PF00153

PRINTS

PR00784
PR00926

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P55916