InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: P4HA3

Summary

InnateDB Protein

IDBP-64212.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P4HA3

Protein Name

prolyl 4-hydroxylase, alpha polypeptide III

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000332170

InnateDB Gene

IDBG-64210 (P4HA3)

Protein Structure

UniProt Annotation

Function

Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269PubMed:12874193, ECO:0000269PubMed:14500733}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in placenta, liver and fetal skin. Weakly expressed in fetal epiphyseal cartilage, fetal liver, fibroblast, lung and skeletal muscle. Expressed also in fibrous cap of carotid atherosclerotic lesions. {ECO:0000269PubMed:12874193, ECO:0000269PubMed:14500733}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004656	procollagen-proline 4-dioxygenase activity
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding

Biological Process

GO:0019511	peptidyl-proline hydroxylation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen

Protein Structure and Domains

PDB ID

InterPro

IPR005123 Oxoglutarate/iron-dependent dioxygenase
IPR006620 Prolyl 4-hydroxylase, alpha subunit
IPR013547 Prolyl 4-hydroxylase alpha-subunit, N-terminal

PFAM

PF03171
PF13640
PF08336

PRINTS

PIRSF

SMART

SM00702

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7Z4N8