InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR1H2

Summary

InnateDB Protein

IDBP-64320.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR1H2

Protein Name

nuclear receptor subfamily 1, group H, member 2

Synonyms

LXR-b; LXRB; NER; NER-I; RIP15; UNR;

Species

Homo sapiens

Ensembl Protein

ENSP00000253727

InnateDB Gene

IDBG-64316 (NR1H2)

Protein Structure

UniProt Annotation

Function

Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	86 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001133	sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0034191	apolipoprotein A-I receptor binding
GO:0043565	sequence-specific DNA binding
GO:0046965	retinoid X receptor binding
GO:0051117	ATPase binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0010875	positive regulation of cholesterol efflux
GO:0010887	negative regulation of cholesterol storage
GO:0030522	intracellular receptor signaling pathway
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032369	negative regulation of lipid transport
GO:0032376	positive regulation of cholesterol transport
GO:0043401	steroid hormone mediated signaling pathway
GO:0044255	cellular lipid metabolic process
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048384	retinoic acid receptor signaling pathway
GO:0048550	negative regulation of pinocytosis
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0060336	negative regulation of interferon-gamma-mediated signaling pathway
GO:2000188	regulation of cholesterol homeostasis

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR003069 Ecdysteroid receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR023257 Liver X receptor

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR00546
PR01283
PR02034

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt