Homo sapiens Protein: CD79B | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-64386.5 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CD79B | ||||||||||||||||||||||
Protein Name | CD79b molecule, immunoglobulin-associated beta | ||||||||||||||||||||||
Synonyms | AGM6; B29; IGB; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000006750 | ||||||||||||||||||||||
InnateDB Gene | IDBG-64384 (CD79B) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. {ECO:0000269PubMed:12097390, ECO:0000269PubMed:8617796, ECO:0000269PubMed:9057631}. | ||||||||||||||||||||||
Subcellular Localization | Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | Agammaglobulinemia 6, autosomal recessive (AGM6) [MIM:612692]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269PubMed:17675462}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||||||
Tissue Specificity | B-cells. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR003110
Phosphorylated immunoreceptor signalling ITAM IPR003599 Immunoglobulin subtype IPR007110 Immunoglobulin-like domain IPR013098 Immunoglobulin I-set IPR013106 Immunoglobulin V-set domain IPR013151 Immunoglobulin |
||||||||||||||||||||||
PFAM |
PF02189
PF07679 PF07686 PF00047 |
||||||||||||||||||||||
PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00077
SM00409 |
||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P40259 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P40259 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 974 | ||||||||||||||||||||||
UniGene | Hs.89575 | ||||||||||||||||||||||
RefSeq | NP_000617 | ||||||||||||||||||||||
HUGO | HGNC:1699 | ||||||||||||||||||||||
OMIM | 147245 | ||||||||||||||||||||||
CCDS | CCDS11655 | ||||||||||||||||||||||
HPRD | 00922 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AK222954 AK223210 BC002975 BC032651 L27587 M80461 M89957 S52229 S79249 X83539 | ||||||||||||||||||||||
GenPept | AAA58387 AAA64459 AAA72424 AAB24822 AAC60654 AAH02975 AAH32651 BAD96674 BAD96930 CAA58522 | ||||||||||||||||||||||