InnateDB Protein
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IDBP-64388.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CD79B
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Protein Name
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CD79b molecule, immunoglobulin-associated beta
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Synonyms
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AGM6; B29; IGB;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000245862
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InnateDB Gene
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IDBG-64384 (CD79B)
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Protein Structure
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Function |
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. {ECO:0000269PubMed:12097390, ECO:0000269PubMed:8617796, ECO:0000269PubMed:9057631}.
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Subcellular Localization |
Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.
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Disease Associations |
Agammaglobulinemia 6, autosomal recessive (AGM6) [MIM:612692]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269PubMed:17675462}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
B-cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004888
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transmembrane signaling receptor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003110
Phosphorylated immunoreceptor signalling ITAM
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PFAM |
PF02189
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PRINTS |
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PIRSF |
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SMART |
SM00077
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TIGRFAMs |
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Modification |
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SwissProt |
P40259
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PhosphoSite |
PhosphoSite-P40259
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
974
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UniGene |
Hs.89575
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RefSeq |
NP_067613
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HUGO |
HGNC:1699
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OMIM |
147245
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CCDS |
CCDS11656
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HPRD |
00922
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IMGT |
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EMBL |
AK222954
AK223210
BC002975
BC032651
L27587
M80461
M89957
S52229
S79249
X83539
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GenPept |
AAA58387
AAA64459
AAA72424
AAB24822
AAC60654
AAH02975
AAH32651
BAD96674
BAD96930
CAA58522
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