InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YME1L1

Summary

InnateDB Protein

IDBP-64423.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YME1L1

Protein Name

YME1-like 1 (S. cerevisiae)

Synonyms

FTSH; MEG4; PAMP; YME1L;

Species

Homo sapiens

Ensembl Protein

ENSP00000318480

InnateDB Gene

IDBG-64419 (YME1L1)

Protein Structure

UniProt Annotation

Function

Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1. {ECO:0000269PubMed:18076378, ECO:0000269PubMed:22262461}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:10843804, ECO:0000269PubMed:22262461}.

Disease Associations

Tissue Specificity

High expression in cardiac and skeletal muscle mitochondria. {ECO:0000269PubMed:22262461}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0007005	mitochondrion organization
GO:0008283	cell proliferation

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000642 Peptidase M41
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR005936 Peptidase, FtsH
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01434
PF00004
PF07724
PF13304

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96TA2