Version 5.4
Homo sapiens Gene: YME1L1
Summary
InnateDB Gene IDBG-64419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YME1L1
Gene Name YME1-like 1 (S. cerevisiae)
Synonyms FTSH; MEG4; PAMP; YME1L
Species Homo sapiens
Ensembl Gene ENSG00000136758
Encoded Proteins
IDBP-64421
YME1-like 1 (S. cerevisiae)
IDBP-64423
YME1-like 1 (S. cerevisiae)
IDBP-64425
YME1-like 1 (S. cerevisiae)
IDBP-237778
YME1-like 1 (S. cerevisiae)
IDBP-370867
YME1-like 1 (S. cerevisiae)
IDBP-811152
YME1-like 1 ATPase
IDBP-811153
YME1-like 1 ATPase
IDBP-811154
YME1-like 1 ATPase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:27110112-27155266
Strand Reverse strand
Band p12.1
Transcripts
ENST00000376016 ENSP00000365184
ENST00000326799 ENSP00000318480
ENST00000375972 ENSP00000365139
ENST00000396296 ENSP00000379590
ENST00000427324 ENSP00000398713
ENST00000463270
ENST00000491542 ENSP00000473557
ENST00000477432 ENSP00000473302
ENST00000613434 ENSP00000481724
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006515 misfolded or incompletely synthesized protein catabolic process
GO:0007005 mitochondrion organization
GO:0008283 cell proliferation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026775
View Gene Order
ENSBTAG00000016445
Not yet available
Cross-References
SwissProt Q96TA2
TrEMBL Q5T8D1 Q5T8D2 Q6PJ89 Q96I63 R4GNA5
UniProt Splice Variant
Entrez Gene 10730
UniGene Hs.598552 Hs.651999 Hs.707548
RefSeq NM_001253866 NM_014263 NM_139312
HUGO HGNC:12843
OMIM 607472
CCDS CCDS58072 CCDS7151 CCDS7152
HPRD
IMGT
EMBL AF151782 AJ132637 AK297973 AL160291 AL162272 AY358484 BC007795 BC019602 BC023507 BC024032 CH471072
GenPept AAH07795 AAH19602 AAH23507 AAH24032 AAK57555 AAQ88848 BAG60283 CAB51858 CAC19650 CAI12217 CAI16906 CAI16907 EAW86068 EAW86069 EAW86070 EAW86071 EAW86072
RNA Seq Atlas 10730

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca