InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SKIL

Summary

InnateDB Protein

IDBP-64484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SKIL

Protein Name

SKI-like oncogene

Synonyms

SNO; SnoA; SnoI; SnoN;

Species

Homo sapiens

Ensembl Protein

ENSP00000259119

InnateDB Gene

IDBG-64482 (SKIL)

Protein Structure

UniProt Annotation

Function

May have regulatory role in cell division or differentiation in response to extracellular signals.

Subcellular Localization

Disease Associations

Tissue Specificity

Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle. {ECO:0000269PubMed:8233802}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 172 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	172 [view]
Protein-Protein	171 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0032403	protein complex binding
GO:0046332	SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007050	cell cycle arrest
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007519	skeletal muscle tissue development
GO:0010467	gene expression
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0042981	regulation of apoptotic process
GO:0045596	negative regulation of cell differentiation
GO:0046677	response to antibiotic
GO:0050772	positive regulation of axonogenesis
GO:0070207	protein homotrimerization
GO:0070208	protein heterotrimerization
GO:0070848	response to growth factor