InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FZD10

Summary

InnateDB Protein

IDBP-64605.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZD10

Protein Name

frizzled family receptor 10

Synonyms

CD350; FZ-10; Fz10; FzE7; hFz10;

Species

Homo sapiens

Ensembl Protein

ENSP00000229030

InnateDB Gene

IDBG-64603 (FZD10)

Protein Structure

UniProt Annotation

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001944	vasculature development
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007420	brain development
GO:0008406	gonad development
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0032855	positive regulation of Rac GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0034259	negative regulation of Rho GTPase activity
GO:0038031	non-canonical Wnt signaling pathway via JNK cascade
GO:0043507	positive regulation of JUN kinase activity
GO:0060070	canonical Wnt signaling pathway
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0042995	cell projection