InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FZD10

Summary

InnateDB Gene

IDBG-64603.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZD10

Gene Name

frizzled family receptor 10

Synonyms

CD350; FZ-10; Fz10; FzE7; hFz10

Species

Homo sapiens

Ensembl Gene

ENSG00000111432

Encoded Proteins

IDBP-64605

frizzled family receptor 10

IDBP-598105

frizzled family receptor 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:130162459-130165740

Strand

Forward strand

Band

q24.33

Transcripts

ENST00000229030	ENSP00000229030
ENST00000539839	ENSP00000438460

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001944	vasculature development
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007420	brain development
GO:0008406	gonad development
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0032855	positive regulation of Rac GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0034259	negative regulation of Rho GTPase activity
GO:0038031	non-canonical Wnt signaling pathway via JNK cascade
GO:0043507	positive regulation of JUN kinase activity
GO:0060070	canonical Wnt signaling pathway
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0042995	cell projection

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000081683

View Gene Order

ENSBTAG00000007047

Not yet available

Pathways

NETPATH

NetPath_8

Wnt pathway

REACTOME

REACT_18372

Class B/2 (Secretin family receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04310

Wnt signaling pathway pathway

hsa05217

Basal cell carcinoma pathway

hsa04916

Melanogenesis pathway

hsa05200

Pathways in cancer pathway

INOH

INOH website

Wnt signaling pathway pathway

INOH website

GPCR signaling pathway

PID NCI

wnt_signaling_pathway

Wnt signaling network

Cross-References

SwissProt

TrEMBL

F5H450

UniProt Splice Variant

Entrez Gene

11211

UniGene

Hs.31664 Hs.624084 Hs.733275

RefSeq

NM_007197

HUGO

HGNC:4039

OMIM

606147

CCDS

CCDS9267

HPRD

05853

IMGT

EMBL

AC026336

GenPept

RNA Seq Atlas

11211