InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF5A2

Summary

InnateDB Protein

IDBP-64665.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF5A2

Protein Name

eukaryotic translation initiation factor 5A2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000295822

InnateDB Gene

IDBG-64663 (EIF5A2)

Protein Structure

UniProt Annotation

Function

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells. {ECO:0000269PubMed:11161802, ECO:0000269PubMed:16519677}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003746	translation elongation factor activity
GO:0005515	protein binding
GO:0043022	ribosome binding

Biological Process

GO:0006452	translational frameshifting
GO:0007283	spermatogenesis
GO:0008284	positive regulation of cell proliferation
GO:0008612	peptidyl-lysine modification to peptidyl-hypusine
GO:0010509	polyamine homeostasis
GO:0015031	protein transport
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045901	positive regulation of translational elongation
GO:0045905	positive regulation of translational termination
GO:0051028	mRNA transport

Cellular Component

GO:0005643	nuclear pore
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001884 Translation elongation factor IF5A
IPR005824 KOW
IPR008991 Translation protein SH3-like domain
IPR012340 Nucleic acid-binding, OB-fold
IPR020189 Translation elongation factor, IF5A C-terminal

PFAM

PF00467
PF01287

PRINTS

PIRSF

PIRSF003025

SMART

SM00739

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt