InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SHANK1

Summary

InnateDB Protein

IDBP-64672.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SHANK1

Protein Name

SH3 and multiple ankyrin repeat domains 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000351984

InnateDB Gene

IDBG-64666 (SHANK1)

Protein Structure

UniProt Annotation

Function

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Colocalizes with alpha-latrotoxin receptor 1. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0017124	SH3 domain binding
GO:0030160	GKAP/Homer scaffold activity
GO:0031877	somatostatin receptor binding
GO:0032403	protein complex binding
GO:0035255	ionotropic glutamate receptor binding
GO:0042802	identical protein binding
GO:0071532	ankyrin repeat binding
GO:0097110	scaffold protein binding

Biological Process

GO:0006461	protein complex assembly
GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007616	long-term memory
GO:0008306	associative learning
GO:0030534	adult behavior
GO:0032232	negative regulation of actin filament bundle assembly
GO:0035176	social behavior
GO:0035418	protein localization to synapse
GO:0050885	neuromuscular process controlling balance
GO:0050894	determination of affect
GO:0060074	synapse maturation
GO:0060997	dendritic spine morphogenesis
GO:0060999	positive regulation of dendritic spine development
GO:0071625	vocalization behavior
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0008328	ionotropic glutamate receptor complex
GO:0016020	membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse
GO:0097481	neuronal postsynaptic density

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001478 PDZ domain
IPR001660 Sterile alpha motif domain
IPR002110 Ankyrin repeat
IPR011510 Sterile alpha motif, type 2
IPR011511 Variant SH3 domain
IPR013761 Sterile alpha motif/pointed domain
IPR020683 Ankyrin repeat-containing domain
IPR021129 Sterile alpha motif, type 1

PFAM