Homo sapiens Protein: TRIM9 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-6471.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | TRIM9 | ||||||||||||||||||||||
Protein Name | tripartite motif containing 9 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000342970 | ||||||||||||||||||||||
InnateDB Gene | IDBG-6467 (TRIM9) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. {ECO:0000269PubMed:20085810}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:20085810}. Cell projection, dendrite {ECO:0000269PubMed:20085810}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle- associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum. {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Brain. Highly expressed in the cerebral cortex (at protein level). Severely decreased in the affected brain areas in Parkinson disease and dementia with Lewy bodies. {ECO:0000269PubMed:20085810}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000315
Zinc finger, B-box IPR001841 Zinc finger, RING-type IPR001870 B30.2/SPRY domain IPR003649 B-box, C-terminal IPR003877 SPRY domain IPR003961 Fibronectin, type III IPR008985 Concanavalin A-like lectin/glucanases superfamily IPR011011 Zinc finger, FYVE/PHD-type IPR018957 Zinc finger, C3HC4 RING-type |
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PFAM |
PF00643
PF13639 PF14634 PF00622 PF00041 PF01108 PF00097 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00336
SM00184 SM00502 SM00449 SM00060 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q9C026 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9C026 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 114088 | ||||||||||||||||||||||
UniGene | Hs.654750 | ||||||||||||||||||||||
RefSeq | XP_005267358 | ||||||||||||||||||||||
HUGO | HGNC:16288 | ||||||||||||||||||||||
OMIM | 606555 | ||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | 05947 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF220036 AF220037 AF220038 AK055388 BC013414 BC063872 CH471078 D87458 | ||||||||||||||||||||||
GenPept | AAG53490 AAG53491 AAG53492 AAH13414 AAH63872 BAA13398 BAB70913 EAW65680 EAW65681 EAW65682 EAW65684 | ||||||||||||||||||||||