InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRIM9

Summary

InnateDB Gene

IDBG-6467.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM9

Gene Name

tripartite motif containing 9

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000100505

Encoded Proteins

IDBP-6469

tripartite motif containing 9

IDBP-6471

tripartite motif containing 9

IDBP-6473

tripartite motif containing 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23438823

TRIM9 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:50975262-51096061

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000298355	ENSP00000298355
ENST00000338969	ENSP00000342970
ENST00000360392	ENSP00000353561
ENST00000555170
ENST00000557456
ENST00000555933

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0016079	synaptic vesicle exocytosis
GO:0016567	protein ubiquitination
GO:0035544	negative regulation of SNARE complex assembly
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045955	negative regulation of calcium ion-dependent exocytosis

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0030425	dendrite

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021071

View Gene Order

ENSBTAG00000010103

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9C026

TrEMBL

UniProt Splice Variant

Entrez Gene

114088

UniGene

Hs.604723 Hs.654750

RefSeq

NM_015163 NM_052978 XM_006720017

HUGO

HGNC:16288

OMIM

606555

CCDS

CCDS45105 CCDS9703

HPRD

IMGT

EMBL

AF220036 AF220037 AF220038 AK055388 BC013414 BC063872 CH471078 D87458

GenPept

AAG53490 AAG53491 AAG53492 AAH13414 AAH63872 BAA13398 BAB70913 EAW65680 EAW65681 EAW65682 EAW65684

RNA Seq Atlas

114088